The 49ers face a significant challenge with both Christian McCaffrey and Jordan Mason on IR, depleting their backfield and necessitating roster adjustments.
Head coach Kyle Shanahan emphasized the need for immediate adjustments, highlighting rookie Isaac Guerendo as the top choice to step into the lead-back role.
Mason's impending free agency adds urgency for the 49ers to evaluate their options, solidifying Guerendo's chance to secure a permanent position.
The 49ers are likely to add another RB to their lineup, with Ke'Shawn Vaughn as a prime candidate given his recent connection to the team.
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