Cian Healy is set to equal Brian O'Driscoll's record as Ireland's most-capped international, preparing to win his 133rd cap off the bench.
Farrell may consider freshening positions like midfield and back-five of the pack, reminiscent of strategic changes made during the second Test win in South Africa.
With Tadhg Furlong nursing a hamstring injury, Farrell may opt to rest him, allowing Finlay Bealham to continue in the front-row for Ireland.
Tom O'Toole is ruled out with a head injury, leading to Thomas Clarkson possibly making his debut off the bench for Ireland this Friday.
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