Reading's recent form has seen them score 13 goals in their last five matches, maintaining an unbeaten streak and setting sights on a play-off position.
Cambridge, struggling after a 2-1 FA Cup loss, has failed to win in their last five appearances while showing significant challenges in away games.
Ruben Selles' men have been strong at home, winning their last seven games at Madejski, adding to their confidence heading into Tuesday's match.
Despite a prior October boost, Cambridge's performance has declined drastically, with their squad facing an uphill battle in the relegation zone of League One.
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