"Researchers at University College Cork, led by Professor Yvonne Nolan, have uncovered the specific metabolic processes that explain how exercise helps offset the harmful behavioral effects of eating a Western-style cafeteria diet. Published on October 21 in the peer-reviewed journal Brain Medicine, the study shows that voluntary running can reduce depression-like behaviors triggered by diets high in fat and sugar."
"Using a comprehensive metabolomic approach, Professor Nolan and her colleagues examined the caecal contents of the animals and found that the cafeteria diet profoundly altered gut metabolism. Out of 175 metabolites analyzed in sedentary rats, 100 were significantly affected. Exercise influenced a smaller subset of these, partially restoring the balance. Three metabolites known to play a role in mood regulation -- anserine, indole-3-carboxylate, and deoxyinosine -- were reduced by th"
Adult male rats were fed either a standard chow diet or a rotating cafeteria diet of high-fat, high-sugar foods for seven and a half weeks, with half of each group given access to a running wheel. Voluntary running produced antidepressant-like behavioral effects even when rats consumed the unhealthy cafeteria diet. Comprehensive metabolomic analysis of caecal contents showed that the cafeteria diet profoundly altered gut metabolism, affecting 100 of 175 metabolites in sedentary rats. Exercise influenced a smaller subset of these metabolites and partially restored metabolic balance. Circulating hormones and gut-produced metabolites were implicated in these effects.
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