The oral antibiotic linezolid does not increase risk for serotonin syndrome in patients taking antidepressants, new research suggests ― contradicting a US Food and Drug Administration (FDA) 2020 warning.Results from a study that included more than 1100 patients who were prescribed linezolid, about 20% of whom were also taking antidepressants, showed that serotonin syndrome occurred in fewer than 0.5% of participants ― and that the percentage was actually lower among those who took antidepressants in comparison with those who did not.
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