"Hormonal headaches typically occur just before menstruation, when estradiol and progesterone levels decline sharply. This hormonal drop elevates stress hormones and increases inflammation, both of which are known triggers for menstrual headaches."
"So, when estrogen drops, it can trigger the onset of a migraine in the days leading up to menstruation. Estrogen also drops very briefly at ovulation, which means you could have a migraine triggered mid-cycle (around two weeks in)."
"Perimenopause (often starting in the mid-30s to early 40s) and menopause (typically between ages 44 and 49) are classic windows for these headaches to emerge."
Estrogen and progesterone declines around menstruation and briefly at ovulation can trigger migraines by causing vasoconstriction of cerebral blood vessels. Hormonal drops also raise stress hormones and increase inflammation, both of which contribute to headache onset. Perimenopause and menopause represent additional high-risk windows when hormonally driven headaches commonly appear. Migraines that occur outside menstrual, ovulatory, or menopausal timing are more likely linked to other factors such as diet, stress, sleep deprivation, trauma, vision changes, or neurological issues. Timing in relation to the menstrual cycle is the primary indicator of a hormonal origin.
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