"At this point, millions of people in the U.S. have tried at least one of a variety of glucagonlike peptide 1 (GLP-1) receptor agonist drugs such as Zepbound or Wegovy. For some, these medications have led to profound weight loss and often improvements in heart health. But many have ended up discontinuing the use of the drugsdespite the fact that they have been touted as lifelong treatments."
"Research published on Wednesday in the BMJ found that people who stopped taking weight-loss drugs, including GLP-1 medications, are likely to see all the weight-loss and heart health benefits disappear in less than two years. The results also indicated that people who discontinue any kind of weight-loss medication regain the weight four times faster than those who stop dieting or working out to shed pounds."
"Weight regain after a period of weight loss is really common, no matter what approach you take, says Sam West, lead author of the study and a research scientist at the University of Oxford, who specializes in integrated metabolism. The fact that people regained weight after stopping medication wasn't too surprising, but what was striking is just how fast it occurred."
Millions of people in the U.S. have tried GLP-1 receptor agonists such as Zepbound or Wegovy. For some, these medications produce profound weight loss and often improve heart health. Many people discontinue the drugs despite recommendations for lifelong treatment. People who stop weight-loss medications, including GLP-1 drugs, typically lose the weight-loss and heart-health benefits within two years. Discontinuing any weight-loss medication leads to regaining weight about four times faster than stopping dieting or exercising. Weight regain after a period of weight loss is common regardless of approach. Evaluated treatments include newer and older GLP-1s, orlistat, and phentermine–topiramate.
Read at www.scientificamerican.com
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