"Lymphedema is a common and debilitating clinical condition," Quaggin said. "The study was designed to unravel the molecules and pathways responsible for proper development of a functional lymphatic system - disruption of lymphatic development results in lymphedema."
Investigators observed activation of PIEZO1 in lymphatic endothelial cells resulted in rapid exocytosis, leading to export of FOXO1, a protein repressing lymphatic valve formation.
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