"C4b-binding protein (C4BP) was identified as the missing cofactor that allows anti-phosphatidylethanolamine (aPE) antibodies to exert their damaging effects, linking them to thrombosis and pregnancy complications."
"The complement system, which C4BP regulates, is part of the body's first line of defense against pathogens, but it must be tightly controlled to prevent damage to healthy tissue."
Northwestern Medicine researchers discovered that C4b-binding protein (C4BP) is a crucial cofactor for anti-phosphatidylethanolamine (aPE) antibodies, which are associated with thrombosis and obstetric disorders. These autoantibodies require C4BP to exert their harmful effects, revealing a mechanism behind autoimmune diseases linked to phospholipids. The complement system, which C4BP regulates, is essential for immune defense but must be controlled to prevent damage to healthy tissues. This finding enhances understanding of how the immune system can harm the body.
Read at News Center
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