"For more than seven years, the Breakthroughs podcast has highlighted the latest high-impact research coming out of Northwestern University Feinberg School of Medicine. Two of the top episodes of 2025 explored drug development for Alzheimer's disease: the effectiveness of new drug to treat Alzheimer's disease and how a new class of drugs work to clear plaques in the brain. Our top episode of the year was about the invention of a tiny pacemaker - the smallest in the world."
"An experimental drug called NU-9 was invented at Northwestern University by Richard Silverman, PhD. The drug has been approved for clinical trials in patients with ALS and may hold promise for other neurodegenerative diseases. In this episode, Silverman and William Klein, PhD, talk about their collaboration to tailor the drug to treat Alzheimer's disease. This discovery is giving scientists hope that the drug could be effective in multiple neurodegenerative diseases by addressing the underlying mechanisms of these diseases."
The Breakthroughs podcast released 17 episodes covering improvements in mental healthcare delivery, precision medicine for rare diseases, bedside medicine, and other clinical topics. The podcast has highlighted high-impact research from Northwestern University Feinberg School of Medicine for more than seven years. Two standout 2025 episodes focused on Alzheimer's disease: one examined a promising experimental drug, NU-9, and another explained how a new class of drugs clears amyloid plaques. NU-9, invented by Richard Silverman, has ALS clinical trial approval and may address shared mechanisms across neurodegenerative diseases after collaboration to tailor it for Alzheimer’s treatment.
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