"What we saw during COVID-19 that was quite peculiar was that a lot of these patients with SARS-CoV-2 pneumonia were on the ventilator for 14 days or even longer, which was pretty surprising to us. Usually when people get pneumonia, they come to the ICU and are there for three or four days on the ventilator," said Luisa Morales-Nebreda, MD, highlighting the unexpected duration of ventilation support in severe SARS-CoV-2 cases.
"T-cells are one of the main immune cells that help patients be protected from pneumonia. We started digging into how lung-specific T-cells are distinct in different causes of pneumonia and to learn anything we can from the number and phenotype of T-cells in the lung; their gene expression profile; their antigenic target; and whether that correlates with clinical outcomes in patients," Morales-Nebreda explained, emphasizing the significance of understanding T-cells for patient outcomes.
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