""This is the first time that a human gene has been linked to a better recovery from stroke," he said in a statement at the time. "Our discovery offers exciting potential for improving patients' health and enhancing their quality of life.""
""We found that maravirocblocked CCR5 in mice and boosted the animals' recovery from traumatic brain injury and stroke," he added. "The big question left to answer was whether eliminating CCR5 would produce the same results in people.""
Researchers identified the CCR5 receptor as a molecular brake on learning and memory and found that CCR5 floods the human brain after stroke or injury. Mice with a natural CCR5 mutation recovered faster and more completely from stroke, indicating CCR5 limits post-injury neural plasticity. The HIV drug maraviroc blocks CCR5 and replicated the mutation's effect in mice, boosting recovery after traumatic brain injury and stroke. Ongoing studies are testing whether maraviroc can enable neural rewiring and improve functional recovery in human patients, based on findings reported in a Cell paper.
Read at Futurism
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