"To explore this issue, Malin and his colleagues enrolled 72 adults considered at risk for metabolic syndrome, which is a cluster of conditions known to raise the likelihood of both diabetes and heart disease. Participants were separated into four groups: high-intensity exercise with placebo, high-intensity exercise with metformin, low-intensity exercise with placebo and low-intensity exercise with metformin. Over a 16-week training period, the research team measured how well participants' blood vessels responded to insulin."
"Metformin appears to diminish exercise-driven improvements in vascular health, fitness, and blood sugar control. Credit: Shutterstock A widely used medication for diabetes prevention may unexpectedly interfere with one of the most reliable ways to lower disease risk: regular physical activity. A Rutgers-led team reported in The Journal of Clinical Endocrinology & Metabolism that metformin appeared to weaken several important benefits normally gained from exercise. These include improvements in blood vessel function, overall fitness and the body's ability to control blood sugar."
Metformin appears to weaken exercise-driven improvements in vascular function, fitness, and glycemic control among adults at risk for metabolic syndrome. Seventy-two at-risk adults were assigned to high- or low-intensity exercise with either metformin or placebo over 16 weeks. Exercise alone increased vascular insulin sensitivity, enabling blood vessels to widen and deliver oxygen, hormones and nutrients more effectively after meals. Combining metformin with exercise diminished those vascular adaptations and blunted gains in overall fitness and blood sugar regulation. Medical guidance since 2006 has often paired metformin with exercise, but the combination may reduce exercise benefits.
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