Investigators led by Pinelopi Kapitsinou, MD, have discovered that inhibiting the hypoxia-driven MCT4 protein may halt the progression of acute kidney injury to chronic kidney disease.
There are currently no approved treatments for acute kidney injury and the kidneys' failure to recover may progress to chronic kidney disease, highlighting a large unmet need for patients.
In severe cases of acute kidney injury, dialysis may be required, but it serves only as a bridge until the kidneys recover, which emphasizes our lack of effective treatments.
Using functional genomics, the scientists discovered that the endothelial oxygen sensing prolyl hydroxylase domain (PHD) enzymes 1, 2, and 3 play a key role in regulating post-ischemic kidney responses.
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