"Some scientists think these body-wide benefits are likely tied to the drugs' weight-loss effects, but growing research suggests another factor may be at play: taming inflammation."
"We have patients [taking GLP-1s] who are telling us, Wow, my arthritis is better,' My Crohn's or colitis is better,' and that motivates us to say, Well, how is that happening?'"
"Research has shown that several metabolic and heart diseases impair the immune system's ability to moderate inflammation, causing harmful levels of inflammation in response to high cholesterol, fat or glucose."
GLP-1 drugs like Ozempic and Zepbound have been approved for treating various conditions, including kidney and liver disease. Research indicates that their benefits may extend beyond weight loss to include anti-inflammatory effects. Scientists are investigating the specific anti-inflammatory pathways activated by these drugs. Patients report improvements in conditions like arthritis and Crohn's disease, prompting further exploration into how GLP-1 drugs influence inflammation. The immune system's response to inflammation is crucial, as chronic diseases can impair its function, leading to harmful inflammation levels.
Read at www.scientificamerican.com
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