This might be the first example of a cell-free electrically conductive device regenerating an organ. The use of cell-seeded materials often complicates manufacturing and clinical implementation, yet materials without cells commonly do not perform well enough for successful translation to patients. Here, we demonstrate that integrating electrically conductive components into a biodegradable elastomer can lead to a manufacturable material that produces biological and functional results that are on par with the gold standard.
Bladder tissue regeneration or augmentation specifically is needed to address neurogenerative diseases in which bladder control and function have become impaired, as well as in cancer. Previous work has shown that cell-seeded citrate-based scaffolds for bladder regeneration demonstrated safety for long-term applications. However, there has remained a need for cell-free biomaterials that are more robust and cost-efficient to manufacture.
#tissue-engineering #bladder-regeneration #biomaterials #electroactive-scaffolds #surgery-advancements
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