Nearly 30 million Americans suffer from migraines, with almost 1 in 4 experiencing at least four severe attacks monthly. Women are three times more likely to suffer from migraines, with an increased risk during reproductive years.
Progesterone and its receptors may impact migraines, with research indicating that this hormone could make those who menstruate more vulnerable to migraines. Hormonal fluctuations during the menstrual cycle, particularly low progesterone levels, may trigger severe menstrual migraines.
During their reproductive cycles, female mice exhibited varying pain sensitivity levels, with higher sensitivity observed when reproductive hormone levels were low. This sensitivity pattern suggests a potential correlation between hormonal fluctuations, particularly progesterone levels, and pain perception.
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