"It's really important that we understand what happens in the healthy brain so that we can better understand what happens when people get these neurodegenerative conditions,"
"If women's brains declined more, that could have helped explain their higher Alzheimer's prevalence,"
Men experience greater reductions in brain volume across more regions during ageing than women. Nearly twice as many women receive Alzheimer's diagnoses as men, and ageing is the biggest risk factor for Alzheimer's disease. Prior research on sex differences in brain ageing has produced mixed results, with some reports of greater male loss of total grey matter and hippocampal size and other reports of sharper female grey-matter decline. More than 12,500 MRI scans from 4,726 cognitively healthy participants (minimum two scans per person, average three years apart) from 14 datasets were analyzed, comparing cortical thickness and sizes of Alzheimer's-associated regions such as the hippocampus.
Read at Nature
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