Lactate, traditionally viewed as merely a waste product, serves a critical role in cancer cell metabolism, enabling them to thrive even in low-oxygen conditions.
Recent metabolomics studies indicate that lactate not only fuels energy production in tumor cells, but also actively contributes to their resistance against chemotherapy treatments.
Understanding the molecular mechanisms by which lactate enhances the survival of cancer cells can reveal potential therapeutic targets to overcome treatment resistance in tumors.
The insights gained from analyzing lactate metabolism in cancer cells could lead to innovative strategies for improving the efficacy of existing chemotherapy protocols.
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