High doses of Adderall are associated with a five-fold increased risk of developing psychosis or mania, particularly in patients taking 30 mg or more.
Researchers found that 81% of psychosis or mania cases among those taking amphetamines could have been prevented with lower dosage, emphasizing the importance of monitoring.
The study indicates a need for caution in prescribing stimulants, especially for patients with pre-existing risk factors for psychosis or mania.
There’s limited evidence that high doses of prescription amphetamines provide greater efficacy, signaling a need for careful dose management by healthcare providers.
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