The efforts to create glucose-responsive insulin have not yielded practical results to date, despite research since the 1970s and various patents and publications in the field. The current mechanisms primarily focus on polymer systems that release insulin in response to glucose fluctuations, but face limitations like delayed glucose diffusion and irreversible insulin release.
A critical limitation of current insulin delivery mechanisms is that they typically release insulin irreversibly, which introduces the risk of hypoglycaemia if blood glucose levels rebound quickly. This lack of reversibility underscores the pressing need for a more sophisticated solution that endows insulin with glucose-responsive properties.
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