"Obesity shaped Anna Olson's earliest notions of herself, when she saw a photo and thought, "Oh, I look different than the other kids." Olson's obesity began in toddlerhood, ran in her family, and left her with a chronic hunger hard to satiate. Dozens of diet, drug and exercise regimens didn't work, and advice from doctors was always the same: Eat less."
"For Olson, genetic testing indicated she likely has several genetic and hormonal factors setting her hunger and satiety sensors out of whack. One of the GLP-1 drugs Ozempic worked briefly, but it turned out another, Zepbound, better recalibrated Olson's hormone imbalance. It was only when she started tackling her specific obesity drivers that Olson began losing lots of weight 65 pounds to date, as she remains on the medicine. "I've been able to keep it off," she says."
Obesity began for Anna Olson in toddlerhood, ran in her family, and produced a chronic, hard-to-satiate hunger. Dozens of diet, drug and exercise regimens failed while doctors repeatedly advised eating less. Science shows obesity involves genetic, biological, neurological, lifestyle, metabolic and behavioral factors, producing many different forms. Successful treatment requires identifying each person's root causes and addressing them. GLP-1 drugs have expanded treatment options and are prompting more tailored care. Genetic testing indicated Olson had genetic and hormonal factors disrupting hunger and satiety; a switch from Ozempic to Zepbound better recalibrated her hormones and enabled 65 pounds of sustained weight loss while remaining on medication.
Read at www.npr.org
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