Investigators altered ACSS1 in mice to mimic an acetylated stage, leading to hypothermia, liver aberrations, elevated blood acetate, decreased ATP, and NAFLD-like symptoms.
RNA sequencing revealed dysregulated fatty acid metabolism and signs of advanced aging in cells, linking ACSS1 dysfunction to NAFLD development.
ACSS1 dysregulation can increase fatty acid production, alter lipid levels, induce cellular aging, and contribute to NAFLD development in mice.
The study emphasizes the biological significance of ACSS1 acetylation under metabolic stress, shedding light on the mechanisms underlying NAFLD pathogenesis.
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