"DNA damage can originate from internal sources like metabolic by-products or normal cellular activities, as well as external factors such as cosmic radiation, diet, and pollution."
"If left unrepaired, primary forms of DNA damage compromise neuronal function and lead to cell death, necessitating a robust DNA damage response in neurons."
"Multiple sclerosis, an autoimmune disease affecting oligodendrocytes, leads to neurological disability and brain atrophy, emphasizing the need for deeper understanding of neurodegeneration mechanisms."
Ageing and neurodegeneration are associated with DNA damage in glial cells and neurons, stemming from both internal and external sources. Unrepaired DNA damage, including single-stranded and double-stranded breaks, can lead to neuronal dysfunction and cell death. Neurons activate a DNA damage response involving various repair pathways. Multiple sclerosis (MS) is a significant cause of neurological disability in young adults, characterized by relapsing-remitting courses and brain atrophy. Understanding neurodegeneration mechanisms in MS is crucial, especially regarding the vulnerability of specific neuron types to injury.
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