The study presents a novel strategy to generate customized viral receptors (CVRs) that mimic native receptors, ultimately enhancing our ability to study coronaviruses lacking known receptors.
By engineering CVRs, we can facilitate key processes associated with viral entry and infection, such as spike proteolytic cleavage and membrane fusion, which are critical for understanding virus behavior.
Through this approach, we effectively rescued wild-type coronaviruses from bat samples, highlighting the strategy's potential for creating relevant infection models that can operate independently from native receptors.
The research reveals how specific CVRs can support the propagation of various coronaviruses, indicating a powerful tool for investigating viruses without previously established target cells.
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