"Alzheimer's disease is driven by the accumulation of abnormal proteins, specifically sticky beta-amyloid that builds up into plaques outside of neurons and tau tangles, or misfolded proteins, within them."
"Despite enormous effort, progress in prevention and treatment has been modest at best, leading researchers to explore alternative explanations and new ways of thinking about a disease that remains uncooperative to understanding."
"By some estimates, 40 percent of dementia cases worldwide are linked to risk factors that can, at least in principle, be modified over the course of one's life."
Alzheimer's disease is a major neurocognitive disorder, often feared by those over 50. It ranks as a leading cause of death among older adults in North America. The amyloid hypothesis, which attributes Alzheimer's to abnormal protein accumulation, has guided research for two decades but has yielded disappointing results. Researchers are now considering alternative explanations and focusing on modifiable risk factors that could potentially reduce dementia cases, emphasizing the importance of lifestyle changes for brain health.
Read at Psychology Today
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