Daily briefing: Why cancer might protect against Alzheimer's disease
Briefly

Daily briefing: Why cancer might protect against Alzheimer's disease
"The chemicals found in a person's breath might reveal the identity of the microbes in their gut. Researchers measured the levels of bacterial metabolites in the exhaled breath of mice and children and showed that they could be used to partially predict the identity and abundance of certain gut bacteria, including one species that is associated with asthma. The findings could lead to devices that help to guide treatment of conditions influenced by gut bacteria more quickly than existing methods that test stool samples."
"Cystatin C, a protein produced by cancer cells, could partially explain why people who have had cancer have a lower risk of Alzheimer's disease. In a study in mice, researchers found that the protein can infiltrate the brain and bind to the molecules that make up the hallmark brain plaques of Alzheimer's disease. This interaction draws the attention of immune cells, which then degrade the plaques. If confirmed in humans, the findings could suggest a path toward new therapies for Alzheimer's, says cancer researcher Jeanne Mandelblatt."
Chemical compounds in exhaled breath can reflect gut microbial metabolites. Researchers measured bacterial metabolites in the breath of mice and children and showed partial prediction of the identity and abundance of certain gut bacteria, including a species associated with asthma. Breath-based metabolite profiles could enable faster, noninvasive devices to guide treatment of conditions influenced by gut bacteria compared with stool testing. The cancer-cell protein cystatin C can infiltrate the brain, bind molecules of Alzheimer's plaques, and recruit immune cells that degrade the plaques in mice, suggesting a potential therapeutic pathway if observed in humans. A US-funded hepatitis B vaccine trial in Guinea-Bissau has provoked controversy, and new non-addictive ADHD medication alternatives are emerging.
Read at Nature
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