Controversial start-up using disembodied human BRAINS for drug testing

Donated human brains from patients with neurodegenerative diseases are kept alive for a short period after death using a machine called BrainEx. The system pumps synthetic blood through the brain’s own vessel network to deliver oxygen and nutrients while maintaining appropriate temperature and conditions. After the brain is connected, experimental drugs are administered immediately. Scientists monitor the brain’s response in real time, collecting data on cells, proteins, and physical reactions. The brains metabolize drugs for about 24 hours, after which the system is stopped and the tissue is processed for further study. The collected data helps determine how long drugs remain in cells, whether they reach targets, and whether side effects occur.

"Bexorg keeps brains alive using a machine it calls BrainEx, which can keep the organ in a temporary state of limbo after death. BrainEx works by pumping a special synthetic blood through the brain's own network of vessels, carrying oxygen and nutrients deep into the tissues. At the same time, the machine's operating system ensures that the organ is kept at the right temperature and in the correct conditions to stay alive."

"Once scientists have hooked the donated organ into BrainEx, they immediately begin administering experimental drugs. Scientists carefully watch how the brain reacts in real time, gathering data on its cells, proteins, and physical reactions. After 24 hours of metabolising various drugs, Bexorg pulls the plug, ending the brain's brief afterlife, before slicing it into hundreds of pieces for further study."

"This allows the researchers to gather critical data, learning how long the drug stays in cells, whether they reach their target, and whether there are any potential side effects. Although it sounds morbid, the scientists behind Bexorg say that this is a better and more ethical way to test"

Read at Mail Online