"Acne has long been dismissed as an unfortunate cosmetic issue a rite of passage that is ultimately of little importance. But that attitude is changing. Many scientists now accept that acne is an attention-worthy condition. Roughly 80% of adolescents worldwide experience acne, which can persist into later adulthood. Because the onset of acne can coincide with the stage of development when self-image is forming, outbreaks can lead to social withdrawal, low self-esteem and even depression."
"Leading that charge are two vaccine candidates that aim to engage the immune system in tackling the underlying cause of acne. Acne is influenced by hormones and genetics, but it is driven by inflammation and lesions caused by bacteria that grow in clogged pores. The vaccines one that would treat the condition and one that would act as a preventive measure both attempt to provoke the immune system into targeting these acne-causing bacteria."
Acne affects roughly 80% of adolescents worldwide and can persist into adulthood. Onset during self-image formation can trigger social withdrawal, low self-esteem and depression. Topical treatments and antibiotics provide only partial, temporary relief; isotretinoin has significant side effects and frequent rebound after treatment ends. There is urgent need for durable therapies that eliminate acne rather than mask symptoms. Two vaccine candidates—one therapeutic and one preventive—aim to engage the immune system to target bacteria that grow in clogged pores and drive inflammation and lesions. Recognition of acne as a disease of immune regulation represents a pivotal shift in treatment strategy.
Read at www.nature.com
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