Van Nistelrooy's interim management sees Manchester United struggling in the Europa League, currently sitting 21st with only one point from three matches under Erik ten Hag.
Despite historical dominance over Greek teams, Manchester United faces a challenge after recent draws, aiming to find their first victory in this season's Europa League.
PAOK is also seeking their first win in the competition, having faced tough losses earlier and only managing a draw against Viktoria Plzen after trailing.
As Manchester United gears up against PAOK, the stakes are high for Van Nistelrooy to reignite the team's European campaign amid managerial changes.
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