Fallout 4 communicates in a lot of ways, but its clearest voice is always death. Death can mean a lot of things in Fallout 4, but if you die and lose more than a few minutes worth of progress, what the game is telling you is to save more often.
Also, maintain a lot of save files. At launch, our friend Chris Plante wrote about the great time he was having in Fallout 4 until he found himself stuck in an elevator after multiple in-game glitches. This is awful, and ideally it won't happen.
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