New research indicates that Ozempic-like drugs, particularly semaglutide, can help reduce biological age by up to three years. The study utilized epigenetic clocks to measure biological age through DNA methylation. Initial blood samples from 184 participants with HIV-associated lipohypertrophy determined their biological ages. Over 32 weeks, half received placebo shots while the other half received active semaglutide jabs. Results showed those receiving the drug became, on average, 3.1 years biologically younger, indicating significant anti-aging effects of the medication.
At the end of the trial, the subjects' blood was collected again - and analysis found that those who received the GLP-1 "became, on average, 3.1 years biologically younger by the end of the study," Dwaraka told New Scientist.
The study determined biological age using so-called "epigenetic clocks," which measure a person's biological age via DNA methylation, or the chemical signals added or removed from DNA as we age.
The basis of this study is what's known as "biological age." As opposed to chronological age, biological age measures how old your body feels.
Chosen because they exhibit "accelerated biological aging, characterized by premature onset of age-related conditions, persistent low-grade inflammation, and metabolic dysfunction," that cohort was uniquely suited for the experiment.
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