Research indicates that the DNA messenger protein HMGB1 can influence aging in cells. The protein is released from aging cells and, when in a reduced form, acts as an 'aging messenger', causing healthy cells to undergo senescence and display signs of aging. Conversely, the oxidized form does not trigger these effects. Experiments on human cell types and mice show that the presence of reduced HMGB1 leads to premature aging, suggesting a possible link between the aging processes of individuals.
The study reveals that injecting the DNA messenger protein HMGB1 from an older individual in healthy cells causes accelerated aging and senescence.
The reduced form of the protein HMGB1 acts as an 'aging messenger', while its oxidized form does not have the same detrimental effect.
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