HIV can enter a dormant-like state and evade treatments, particularly hiding in the brain where the blood-brain barrier complicates access for antiretroviral medications.
The drug BLZ945 specifically targets macrophages, which are responsible for spreading HIV in the brain. By inhibiting these immune cells, potential HIV elimination may be possible.
In a study treating primates with SIV, BLZ945 reduced macrophage levels in the brain significantly, demonstrating its potential to lower brain-based viral loads.
This research highlights the ongoing challenge HIV poses even with available treatments, as finding a complete cure remains elusive due to viral reservoirs in the body.
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