
"The only way that they work is if you keep taking them. And when people stop taking them, they have a lot of weight regain, and the medical problems that went away tend to come back. Scott Isaacs, an endocrinologist at the Grady Health System in Atlanta, explains the dependency on continuous GLP-1 medication use for maintaining weight loss and metabolic improvements."
"New research from the University of Oxford found that weight is projected to return to pretreatment levels within about 1.7 years after stopping medications. Improvements in cardio-metabolic markers-including blood pressure, cholesterol, and diabetes-related indicators-also trend back toward baseline within about 1.4 years after cessation."
"In a study published last year, researchers analyzed the health records from 77,310 adults in Denmark who used Wegovy for the first time. The researchers found that 52% of people stopped taking the drug within a year, pointing to cost and side effects, which have become growing concerns for users worldwide."
GLP-1 medications effectively reduce weight, but benefits are temporary and dependent on continuous use. Research from the University of Oxford shows weight returns to pretreatment levels within approximately 1.7 years after stopping medication, with improvements in blood pressure, cholesterol, and diabetes markers reverting to baseline within 1.4 years. Over half of patients discontinue GLP-1 drugs within one year due to cost and side effects. Annual out-of-pocket expenses exceed $4,200, making long-term treatment financially unsustainable for many patients. Medical complications that prompted initial treatment tend to reappear once medication ceases, requiring indefinite commitment for sustained benefits.
#glp-1-medications #weight-loss-sustainability #medication-discontinuation #cost-barriers #metabolic-health
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