"There is a lot of interest today in identifying ways to not just live longer, but to live better. It was exciting to see the benefits of a multivitamin linked with markers of biological aging. This study opens the door to learning more about accessible, safe interventions that contribute to healthier, higher-quality aging."
"Epigenetic clocks estimate biological aging based on tiny changes in DNA. These clocks look at specific sites in our DNA that regulate gene expression (known as DNA methylation) and change naturally as we get older, helping track mortality and the pace of aging."
"The new study, which uses data from the well-established COcoa Supplement Multivitamins Outcomes Study (COSMOS), analyzed DNA methylation data from blood samples of 958 randomly selected healthy participants with an average chronological age of 70."
Researchers from Harvard and Mass General Brigham analyzed data from a large randomized clinical trial examining the effects of daily multivitamin supplementation on biological aging in older adults. Using epigenetic clocks that measure DNA methylation changes, they tracked five biological aging markers over two years in 958 healthy participants with an average age of 70. Results showed multivitamin use slowed biological aging by about four months. Participants who were biologically older than their actual age at baseline experienced the greatest benefits. Epigenetic clocks estimate biological age by analyzing specific DNA sites that regulate gene expression and naturally change with aging, providing markers for mortality risk and aging pace.
Read at Harvard Gazette
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