The scale and tragedy of the U.S. opioid epidemic have few comparisons. More than 100,000 people have died of overdoses every year since 2021. Most drug overdose deaths have a single culprit: the extremely potent synthetic opioid fentanyl.
Overdose deaths have declined slightly overall since last fall, including those from opioids like fentanyl. However, the current death toll remains alarmingly high, above pre-pandemic levels, showing a provisional and potentially undercounted figure.
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