The screening will be the world premiere of the film, which reunites original stars Michael Keaton and Winona Ryder with Burton.
Burton's sequel, Beetlejuice Beetlejuice, takes place 36 years after the original movie, featuring new cast members Jenna Ortega and Monica Bellucci.
The film has been in development for decades, with versions dating back to the late 1980s, showcasing Burton's enduring commitment to the project.
The opening slot at Venice is highly prestigious, often leading to awards success, with past films like La La Land and Birdman making their debut there.
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