Murphy made his professional acting debut in 1996 in Disco Pigs, which toured for two years, kickstarting his career.
His lead role in 28 Days Later in 2002 gained attention, leading to a Breakthrough Male Performance nomination at the 2004 MTV Movie Awards.
Intermission in 2003 became Ireland's highest-grossing indie film until 2006, starring Murphy alongside Colin Farrell.
In 2005, Murphy played Dr. Jonathan Crane in Batman Begins, marking the beginning of his collaboration with director Christopher Nolan.
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