Our palms don't have oil glands, so I moisturize my hands three or four times a day. I use a moisturizing hand wash from Dove and then apply Neutrogena's Norwegian Formula Hand Cream—it has petroleum in it to prevent water loss, but not so much that it leaves hands oily and sticky.
At night, I apply a hand mask. Aquaphor has a good one. I also love wearing gel-lined gloves to bed; they're great for locking in moisture overnight.
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