Human genetics plays a crucial role in identifying and prioritizing potential drug targets, providing insights into drug effects, dose-response relationships, and safety risks.
Genome-wide association studies (GWASs) may have initially faced skepticism due to identifying small-effect variants but can still contribute to successful drug target identification.
Genetic support from GWASs is somewhat less predictive of drug target advancement compared to support from Mendelian diseases.
There are many open questions regarding the application of genetic evidence in drug discovery, including characteristics of genetic associations that differentiate successful from unsuccessful drug mechanisms.
#human-genetics #drug-discovery #genome-wide-association-studies #drug-development-pipeline #genetic-associations
Collection
[
|
...
]