"There are no approved treatments or vaccines against Ebola Bundibugyo virus, which has been linked to 336 suspected cases and 88 deaths, according to data from the US Centers for Disease Control and Prevention as of on 17 May."
"Nature has learned that a World Health Organisation (WHO)-sponsored clinical trial of two experimental treatments for Ebola Bundibugyo virus disease is in the works, pending approval by the governments of DRC and Uganda. Health officials are also considering whether an approved vaccine for another species of Ebola virus could be trialled in the current outbreak."
"Rojek, who is part of a WHO effort to rapidly trial treatments against filoviruses, which includes Ebola and Marburg viruses, during outbreaks, says the trial will focus on two therapies. One is the broad-acting antiviral called remdesivir, which is manufactured by Gilead Sciences in Foster City, California. The other is a treatment called MBP134, which is a mixture of two antibodies that recognize diverse Ebola viruses and was developed by Mapp Biopharmaceuticals in San Diego, California."
"Remdesivir was trialled in a 2018-2019 DRC outbreak of another species of Ebola virus called Zaire, as well as against SARS-CoV-2 during the global pandemic, where its efficacy was modest. MBP134 was administered in a 2022 outbreak of the Sudan species of Ebola in Uganda, but this was done outside of a clinical trial under 'compassionate use' in which patients with a life-threatening disease can get access to investigational therapies."
A rare Ebola species, Ebola Bundibugyo virus, is spreading in the Democratic Republic of the Congo and Uganda. No approved treatments or vaccines exist for this virus. Data from the US Centers for Disease Control and Prevention report 336 suspected cases and 88 deaths as of 17 May. A WHO-sponsored clinical trial of two experimental treatments is planned, pending government approval in both countries. The trial targets remdesivir, a broad-acting antiviral, and MBP134, a mixture of two antibodies designed to recognize diverse Ebola viruses. Officials are also considering whether an approved vaccine for another Ebola species could be tested during the outbreak.
Read at Nature
Unable to calculate read time
Collection
[
|
...
]