Carson Kelly had three hits, including the go-ahead RBI single in the 10th inning, and Mark Canha finished a triple short of the cycle to lift the Tigers to a 7-6 win.
Luis Robert Jr. was 3-for-4 with two home runs and four RBIs for the White Sox, despite their loss.
Shelby Miller retired the final six White Sox to earn the win for Detroit.
Kenta Maeda had a rough outing for the Tigers, allowing several runs and hits in 3 1/3 innings.
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