The White Sox have won just two of their first 15 games, eclipsing the 1968 team, which started 3-12.
Chicago has dropped seven of its first eight home games. The White Sox are reeling without three of their best players, each on the injured list.
"You are trying to play hard every single day," White Sox left fielder Andrew Benintendi said.
The Royals will send right-hander Seth Lugo (2-0, 1.45 ERA), who will be making his fourth start of the season.
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