Andy Ibáñz snapped a tie with a pinch-hit single in the ninth, sending the Tigers to a 3-2 victory over the Chicago White Sox.
Each of the Tigers' wins in the season-opening series at Chicago was decided by one run.
Flaherty gave up a run and four hits while striking out seven.
Canha was thrown out at home in the sixth, bumping into catcher Lee, leading to a brief exchange of words.
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