The Twins will play at Busch Stadium in St. Louis on March 27, 2025, marking their earliest Opening Day in franchise history, followed by three road games before the home opener against the Astros on April 3.
Twins starting the 2025 season on the road for the 12th time in 16 seasons post-Metrodome, playing 10 of the first 13 games away to avoid late-March snowstorms.
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