"The study reveals that mechanical strain on the heart could explain the rarity of cardiac tumors, as beating hearts inhibit cancer cell growth more effectively than static tissues."
"In experiments, cancer cells injected into transplanted hearts without beating proliferated rapidly, replacing most healthy cells, while only about 20% of the native beating hearts became cancerous."
"Engineered heart tissue experiments demonstrated that cancer cells grew more in static tissue than in beating tissue, where they clustered in outer layers, indicating the protective role of heart contractions."
Research indicates that the mechanical strain from a beating heart prevents cancer cell proliferation. In experiments, cancer cells thrived in non-beating transplanted hearts but were less prevalent in native beating hearts. The study also showed that engineered heart tissue with no beating allowed for more cancer cell growth compared to beating tissue, where cancer cells clustered in outer layers. This suggests that the heart's rhythmic contractions play a crucial role in limiting tumor development.
Read at Nature
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