Recent research by Northwestern Medicine scientists has uncovered that the testis-specific protein BRDT significantly contributes to tumor growth and progression in lung cancer. By suppressing BRDT in laboratory models, researchers found that tumor progression slowed and survival rates increased, indicating its essential role in lung cancer. The study also revealed a complex relationship between BRDT and another cancer-driving protein, BRD4, both of which regulate gene expression but perform distinct functions critical for cancer development, suggesting a potential therapeutic avenue against lung cancer.
In the study, Wang and his collaborators developed cell lines derived from patients with small cell lung cancer. When BRDT was suppressed in lung cancer cells, it significantly slowed tumor progression and extended survival in laboratory models.
Basically, BRDT is a testis-specific version of BRD4 and is mis-expressed in lung cancer and we think that drives cancer,
We tested the depletion of BRDT by in-vitro studies and also in animals and we've demonstrated that this protein is essential for the lung cancer tumor growth in animals.
The study also highlights the complex relationship between BRDT and a related cancer-driving protein, BRD4. While the two share some overlapping functions, BRDT was found to perform certain distinct tasks critical to cancer development.
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