"The man received a bone marrow donation from his brother, who has a rare genetic mutation called CCR532 that confers resistance to HIV-1, the most common type of human immunodeficiency virus."
"After the transplant, the donor cells had replaced the HIV-positive man's bone marrow cells and their genes had two copies of a CCR532 mutation."
"His healthy T cell count soared in the year after the procedure and stayed at healthy levels after he stopped antiretroviral therapy two years later."
"They found no detectable HIV in the places it would normally linger in someone who was on ART."
A 63-year-old man has functionally cured his HIV after receiving a bone marrow transplant from his brother, who has the CCR532 mutation that provides resistance to HIV-1. This is the first instance of such a successful transplant from a sibling. The transplant replaced the recipient's HIV-positive bone marrow cells with donor cells carrying the CCR532 mutation, leading to a significant increase in healthy T cell counts. Testing revealed no detectable HIV in typical reservoirs, although concerns about potential viral rebound remain if not all tissues are affected.
Read at www.scientificamerican.com
Unable to calculate read time
Collection
[
|
...
]