Researchers at Northwestern University have identified a new role for the protein Exportin-1 in promoting gene transcription. Known for its function in transporting materials out of the nucleus, Exportin-1 also facilitates gene expression by linking transcription factors to nuclear pore proteins, driving genes to the nuclear periphery where they can be more actively expressed. This discovery is particularly relevant as Exportin-1 is often overexpressed in various cancers, suggesting its role in tumorigenesis. The study provides new insights into gene regulation and may have broad implications across different eukaryotic organisms.
Exportin-1, also known as Xpo1 or Crm1, has a newly discovered role in aiding gene transcription by linking transcription factors to nuclear pore proteins.
This research sheds light on Exportin-1's dual functions in nuclear biology, revealing its involvement in both material export and gene expression enhancement.
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